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With the increasing cost and limited supplies of fish feed protein, HFDs are used currently in aquaculture for their protein sparing effect, which means that the energy that is normally sourced from protein consumption is replaced by lipid-sourced energy 11,12

Meta-analysis of randomized controlled trials demonstrates that ALA can significantly improve neuropathic pain and nerve conduction velocity

In addition, carnitine can also activate glucocorticoid receptor (GR) and regulate glucocorticoid- responsive genes through this mechanism, playing a role in glucocorticoid regulation [81], and reducing glucocorticoid-induced muscle atrophy in patients with pemphigus [82]