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One study associated exclusively nuclear IGF-1R with better progression-free and overall survival in patients with soft tissue sarcomas, Ewing sarcomas and osteosarcomas treated with IGF-1R-directed antibodies [137]

In contrast, individuals with UC exhibit gut dysbiosischaracterized by a reduction in beneficial bacteria such as Faecalibacterium prausnitzii and Bifidobacterium , and an increase in potentially pathogenic microbes like Escherichia coli