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PJ011862032021) Rural Development Administration, Republic of Korea

While enzymes such as glutathione peroxidase 4 (GPx4) typically utilize cellular glutathione (GSH) stores to scavenge lipid hydroperoxides and prevent LPO-induced damage, erastin-mediated inhibition of cysteine uptake through the Xc- transporter compromises this defense strategy, leading to cell death

Protandim is a dietary supplement that contains a combination of natural ingredients designed to activate Nrf2 and enhance the body's antioxidant defenses

Experts say the unauthorized products fall into regulatory grey zone, with limited evidence of safety and risks that include hormonal imbalances, the growth of cancerous tumours, and liver or kidney damage