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Measurement of L-carnitine biosynthesis intermediates revealed elevated -BB levels in plasma and urine (Table 1)

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Because UBR5 appears to stably associate with OTUD5 26,27 , and because TRIP12 possesses phosphorylation sites ( we presume that TRIP12 may associate with OTUD5 under certain cellular conditions, triggering rapid OTUD5 degradation to fulfill cellular demand