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They are foundational tools in early-stage discovery and analytical chemistry

Yeast MCK1 protein kinase autophosphorylates at tyrosine and serine but phosphorylates exogenous substrates at serine and threonine

GPX4 deficiency increases ferroptosis susceptibility, as seen in systemic lupus erythematosus, where suppressed GPX4 induces neutrophil ferroptosis [65]