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Importantly, in the patients bearing tumors with NRF2-KEAP1 alteration a significantly increase in expression of NRF2 target genes was observed, such as NQO1, and the enzymes responsible for GSH synthesis, GCLC and GCLM, which indicates that GSH levels are also higher (Fig

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Major limitations of this observation include potential underreporting of cases due to mild symptoms or lack of awareness

Wnt signaling pathway The Wnt signaling pathway has been previously reported to serve an important role in melanogenesis (24,25)