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however, some studies show that hypoxia inhibits the viability and proliferation of AD-MSCs and NP-MSCs while promoting chondrogenic differentiation ( Other MSCs such as placenta-derived (PMSCs), annulus fibrosus-derived (AF-MSCs), and peripheral blood-derived (PB-MSCs) also show enhanced proliferation, migration, or stemness under hypoxia (Ni et al., 2014

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DNA sequences of cysI and cysH and a model for the siroheme-Fe 4 S 4 active center of sulfite reductase hemoprotein based on amino acid homology with spinach nitrite reductase

Interestingly, although previous evidence has suggested that AD patients generally demonstrate progressive deterioration in brain perfusion and clinical symptoms, a recent SPECT study depicted an increase in the perfusion of the precuneus in AD patients after the administration of ALC, along with a lack of further deterioration of cognitive and neuropsychiatric symptoms [52]