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In addition, iron acts as the active center of lipoxygenase, which oxidizes polyunsaturated fatty acids on cell membranes through an iron-ion-dependent chain reaction, thereby promoting the proliferation of phospholipid peroxides and thus causing ferroptosis

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In contrast, local, endogenous sympathetic tone has been shown to be crucial for dynamic daily changes in adhesion molecule expression in the bone marrow and skeletal muscle, acting as a key signal to the endothelium and stromal cells to regulate immune cell trafficking

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43 DixonD

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Front Biosci S4(2):286 Lee JA, Son HJ, Park KD, Han SH, Shin N, Kim JH et al (2015) A novel compound ITC-3 activates the Nrf2 signaling and provides neuroprotection in Parkinsons disease models

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