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described a potent relaxant property of berberine on tracheal smooth muscle mediated through histamine (H1) receptor antagonism, along with inhibition and nitric oxide production and COX pathways (Saadat et el., 2019)

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Collectively, these observations indicate that, despite their similar BMI, obese subjects with low IGF-1 levels are markedly more predisposed to have multiple metabolic abnormalities, such as increased adiposity, inflammation, dyslipidemia and hyperuricemia than subjects in the standard IGF-1 range

[2] The anti-inflammatory dimension dampening of pro-inflammatory cytokine signaling and support of antioxidant defenses is proposed as the mechanism that keeps the repair environment from tipping into chronic inflammation and fibrosis