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Similarly, enzymes such as bromelain, papain, pronase and trypsin immobilized on particle surfaces can efficiently cleave amide bonds within mucin glycoproteins to boost particle mobility 199,208

In fact, the use of GSTP1 knockout mice demonstrated that loss of GSTP1 expression increases sensitivity to metabolic or environmental toxins and promotes mutations and cancer development ( FIGURE 2 Prostate cancer Promoter hypermethylation leading to epigenetic silencing of GSTP1 gene expression is frequently detected in prostate cancer cells, the most commonly diagnosed type of malignancy among men in Western European countries and the second cause of cancer-related deaths among men worldwide ( Figure 2 )

EMBO Mol Med 9(5):589604 Zou X, Zou X, Gao L, Zhao H (2024) Gut microbiota and psoriasis: pathogenesis, targeted therapy, and future directions