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Data availability The expression datasets analyzed for this study can be downloaded from the TCGA database ( The correlation between drug sensitivity and mRNA expression was analyzed using the Gene Set Cancer Analysis (GSCA) database ( The relationships between sorafenib and four ferroptosis-related genes in RCC were analyzed using the Genomics of Drug Sensitivity in Cancer (GDSC) database ( All data generated or analyzed during this study are included in this article

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Further, oxidative damage to phospholipids can induce ferroptosis, as described earlier, which has now been directly linked to the induction of neuroinflammation ( Discussion Together, these studies examining oxidative stress, redox dysregulation, metabolic alterations, and neuroinflammation suggest that these processes are all not only involved in the pathogenesis of epilepsy, but fundamentally linked (See Scheme 1)