glutathione peroxidase acetaminophen Sex differences in metabolism and toxicity GSH reduces NAPQI, the metabolite
GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses PMC Up regulation of nuclear related factor 2 (NRF2) and antioxidant responsive elements by metformin protects hepatocytes against the acetaminophen toxic Toxicology Research (RSC Publishing) DOI:10.1039 C4TX00032C The conjugation of acetaminophen by glutathione and cytochrome P450. Download Scientific Diagram
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