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Reported results have shown that the addition of pharmacological ascorbate to platinum-based chemotherapy significantly improves tumor deterioration in the advanced stage of NSCLC, by meeting its primary endpoint with an objective response rate of 34.2% and reaching a disease-control rate of 84.2%

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Glossary ROS reactive oxygen species Fe 2+ ferrous iron PUFAs polyunsaturated fatty acids GPX4 glutathione peroxidase 4 ACSL4 acyl-CoA synthetase long-chain family member 4 PTGS2 prostaglandin-endoperoxide synthase 2 GSH glutathione SLC7A11 solute carrier family 7 member 11 RSL3 (1S,3R)-RSL3 PRDX3 peroxiredoxin 3 SARS-CoV severe acute respiratory syndrome coronavirus HBV hepatitis B virus EBV Epstein-Barr virus RV rotavirus H1N1 pandemic influenza A virus subtype H1N1 JEV Japanese encephalitis virus P

ESA doses also tended to increase, although the difference was not statistically significant