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Science 291 , 10011004 (2001)

Horizon requires a confirmed type 2 diabetes diagnosis (ICD-10 E11.x), A1c of 6.5% or greater, and documented trial or failure of metformin (and often one additional agent)

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Some of the key roles of B12 in your body include: Helping in the normal functioning of the nervous system Playing a vital role in DNA synthesis B12 is among the vitamins needed in the breakdown of amino acids and fatty acids Helps in the creation and maturation of red blood cells (hemoglobin) in the bone marrow Supports the production of digestive enzymes and the delivery of essential nutrients to and from cells Its vital to the development of a fetus in pregnant women Vitamin B12 deficiency can cause different symptoms, such as fatigue, anemia, headaches, pale skin, vision problems, mouth/tongue sores, weakness, and changes in cognitive functioning