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A recent study reported that nasal administration of TiO 2 -NPs (2.510 mg/Kg/90 days) to mice caused neuronal death in the hippocampus, oxidative stress and gliosis, and microarray analysis revealed a decline of genes associated with memory and cognition (Ze et al., 2014)

By February 2023, with over 674 million people diagnosed with Coronavirus Disease 2019 (COVID-19), the death toll exceeded 6.86 million patients worldwide 4

Therefore, it is interesting that 2-AAA was decreased in the group with L-carnitine administration, as it suggested a possible decrease in risk for diabetes