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Genome-wide knockout, knockdown, and activation screens are now systematically revealing both canonical and unexpected regulators of autophagy, mitophagy, UPS function, and ER stress adaptation

HGF phosphorylates MET, ERK, and AKT (Shin et al., 2017

Neuroinflammation 20:261

In this process, exercise-induced lactate accumulation can trigger the lactate clock, promoting the transition of microglia to a reparative phenotype [47]