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[PMC free article: PMC2156132] [PubMed: 10459021] 128

Retrieved 2025-10-06

Older adults are at increased risk due to age-related changes in the digestive system

The Arg3 to Leu3 substitution disrupts a key contact residue in the IGFBP binding interface, and the N-terminal extension further sterically interferes with binding pocket access