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These modifications were also linked to the enhanced integrity of the gut barrier, thus safeguarding against inflammation caused by heart failure at both local and systemic levels

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Of note, the arousal stimulator noradrenalin, whose concentration in brain peaks during daytime, has been shown to induce oxidative stress and apoptosis in cultured oligodendrocyte progenitors (Khorchid et al., 2002), whereas acetylcholine that is elevated during the wake state and REM sleep, has been shown to promote mitotic expansion of oligodendrocyte progenitors (Paez-Gonzalez et al., 2014

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