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Folate supports: Red blood cell formation DNA synthesis Cellular growth and division Homocysteine metabolism Homocysteine is an amino acid that may become harmful when levels are elevated over time

It is inferred that the transcriptional activation of interferon-stimulated genes (ISGs), including CD38, results from signal transduction after IFN-/ binding to the type 1 interferon (IFN) receptor, activation of janus kinase 1 (JAK1), signal transducers and activators of transcription 1/2 (STAT1/2) and interferon regulatory factor 9 (IRF9), assembly of the IFN-stimulated gene factor 3 (ISGF3) complexes that translocate to the nucleus and bind to IFN-stimulated response elements [99]

Lenalidomide is a second-generation IMiD with fewer side effects in older patients than the first generation of IMiDs

However, an underlying assumption in this analysis is that patients will comply with oral therapy