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Moreover, the immunosuppressant activity of OTA is characterized by size reduction of vital immune organs, such as thymus, spleen, and lymph nodes, depression of antibody responses, alterations in the number and functions of immune cells, and modulation of cytokine production (TNF- and Il-6)

demonstrated that lactate promotes PFKFB3-driven angiogenesis through AKT phosphorylation [22], while lactate also induces EC permeability via extracellular signal-regulated kinase (ERK)-dependent activation of calpain1/2 to disrupt vascular endothelial (VE)-cadherin [53]

According to its symptoms and pathogenesis, NAFLD can be recognized as a hepatic syndrome such as distention and fullness, phlegm syndrome, turbidity, hypochondriac pain, a lump at the left hypochondrium and damp obstruction disease [8]

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