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The generally accepted theory is, after vascular extravasation, the spirochaetes colonize the ECM of multiple tissues and organs, which contain molecules that can be bound by Borrelia

Given this, and also because of a very high inter-individual variability of TL in same-age individuals, longitudinal research of intra-individual rates of age-related decline in TL is likely a more useful design than the cross-sectional one in studying the relationship between TL and mortality