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Spadin modulates astrocytic passive conductance via inhibition of TWIK-1/TREK-1 heterodimeric channels

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(2024) CNS Neuroscience & Therapeutics , 30(3): e14676 Confirmed ARA-290 provides neuroprotection in a mouse MCAO cerebral ischaemia model via CR, significantly reducing neuronal apoptosis and inflammatory cytokines, equivalent to EPO neuroprotection but without erythropoietic side effects