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Hauck EW, Hauptmann A, Bschleipfer T, Schmelz HU, Altinkilic BM, Weidner W

Death rates (DR) varied from 0.22/ 100,00 (Argentina) to 15.1/100,000 (Chinese Taipei)

The functional distinction between the enzymes terminal extensions is further demonstrated by structural analyses: the N-terminal extension seems to maximize substrate binding in alkaline environments through better cavity interactions and structural stabilization, whereas the C-terminal extension improves acid tolerance

In response to signals such as IFN-, Toll-like receptor agonists, or IL-4/IL-13, macrophages can respectively enter classical activation (M1) or alternative activation (M2) states