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The development of second-generation tetracyclines, including doxycycline and minocycline, has revealed non-antibiotic properties, such as inhibition of matrix metalloproteinases (MMPs), antioxidant, immunomodulatory, antiproliferative, and antiapoptotic activities

Methionine is subsequently adenylated by MAT to form SAM, the universal methyl donor utilized by DNA, RNA and histone methyltransferases

Design of these biosensors involves creation of two fusion proteins, each containing a split Ssp DnaE intein fragment and a fragment of a reporter protein (GFP or luciferase)

Phytomedicine 15(11):940945 Wang CP, Wang Y, Wang X, Zhang X, Ye JF, Hu LS, Kong LD (2011) Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice