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The nomination included no clinical data, and FDA found no medical literature where TB-500 was administered to patients for any condition, including wound healing

The perturbed glutamine-glutamate metabolism induced neurotransmitter imbalance and created an immune-inhibitory state with increased gamma-aminobutyric acid/glutamate ratio, thus facilitating efficient viral replication both in JEV-infected neurons and the brain of JEV-infected mice

these individuals had significantly lower vitamin D levels compared to healthy individuals and patients with depression but no suicidal tendencies [51]