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Pro-inflammatory macrophages and effector T cells predominantly rely on glycolysis to sustain their inflammatory functions, whereas anti-inflammatory macrophages and regulatory T cells preferentially utilize oxidative phosphorylation and fatty acid oxidation (24)

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On the one hand, TME immunomodulation can trigger macrophage polarization from alternately activated macrophages M2 to classically activated macrophages M1, offering intertumoral H 2 O 2 for the Fenton reaction (Zanganeh et al., 2016), which effectively generates ROS and triggers lipid peroxidation (Yang and Stockwell, 2016

Arch Dis Child Fetal Neonatal Ed 93 : F153F161 Miura S, Ishida-Nakajima W, Ishida A, Kawamura M, Ohmura A, Oguma R, Sato Y, Takahashi T 2009 Ascorbic acid protects the newborn rat brain from hypoxic-ischemia