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Eisner and H.I

Ebselen was found to increase the expression of GPX1 in SGNs after peroxynitrite damage, which is consistent with the reports that ebselen can increase the expression of GPX1 in cochlea after electrical stimulation ( gpx1 / mice leads to the aggravated SGN injury (cell loss and apoptosis) induced by peroxynitrite, although it might cause no effect on SGN development as SGNs presented normal morphology and cell number in gpx1 -deficient mice

Increased aromatase expression 53 and StAR protein levels and P450scc mRNA 116 were elevated in response to in vivo exposure in Atlantic salmon, suggesting estrogen stimulating effects

Other methods, like intravenous injection, can be difficult and costly