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Leung, W

The phosphoinositide-gated lysosomal Ca (2+) channel, TRPML1, is required for phagosome maturation

Age, family history, and the presence of the apolipoprotein E 4 allele have been found to be significant risk factors for the development of Alzheimer disease and all-cause dementia.1-3 More recently, a high plasma concentration of homocysteine has also been shown to be a risk factor for Alzheimer disease and dementia.4 Docosahexaenoic acid (DHA), an -3 polyunsaturated fatty acid found in some foods and many tissues in the body, also appears to be important in affecting the risk of dementia

Given that orally administered prebiotics and postbiotics have been shown to improve pulmonary health in calvespotentially through modulation of the gut lung axisthe oral microbiome, as a nodal point within this axis, represents an accessible intervention point warranting further investigation in bovine-specific models