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J Hum Genet 1998

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An increasing body of evidence suggests that the gut microbiota and neuroendocrine system, both of which are linked to conditions such as irritable bowel syndrome and depression, engage in bidirectional communication

These pharmacological agents primarily exert their therapeutic effects through mechanisms such as the suppression of inflammation, reduction in histamine release, prevention of mast cell degranulation, and alleviation of tissue edema