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Compared with free drugs, contrast agents can more effectively achieve ultrasound imaging and ferroptosis via PTT treatment, stimulate systemic immune responses, and inhibit not only liver carcinoma in situ but also lung metastasis

These changes are crucial for cellular adaptation to pathological environments, enabling survival and the maintenance of physiological functions

Similarly, curcumin and the sirtuin inhibitor FK866 attenuate lung inflammation and apoptosis via fine-tuning NF-B signaling and reducing pro-inflammatory cytokine release[50, 53]

Chronic inflammation and liver cirrhosis are the predisposing factors in the development of HCC