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Characterization of the acid-labile subunit of the growth hormone-dependent insulin-like growth factor binding protein complex

Only a small percentage of a standard oral dose is absorbed through this active pathway, and that number drops further when digestion is impaired

This occurs because the enzyme, dihydrofolate reductase, has limited capacity to reduce folic acid in mammalian cells, particularly in human cells (68)

However, the largest Phase IIb trial involving 536 subjects failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading Metabolic Pharmaceuticals to terminate development in 2007