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The observation that Lewy pathology can spread into adjacent healthy neurons has given rise to the postulate that prion-like propagation of -synuclein aggregates may be occurring

doi: 10.3389/fphys.2020.609103 Received 22 September 2020 Accepted 24 December 2020 Published 20 January 2021 Volume 11 - 2020 Edited by Lars Kaestner, Saarland University, Germany Reviewed by Mauro Magnani, University of Urbino Carlo Bo, Italy

For example, it has been shown that AR can directly bind the enhancer element within the SOX2 promoter in prostate cancer cells, resulting in the inhibition of SOX2 transcription [94]

They believe that high oxidative stress in these animals leads to mutations in the virus, causing it to become virulent