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Kanakkanthara A, Kurmi K, Ekstrom TL, Hou X, Purfeerst ER, Heinzen EP, Correia C, Huntoon CJ, OBrien D, Wahner AE, Hendrickson SC, Li DH, Oberg AL, Hitosugi T, Kaufmann SH, John Weroha S, Karnitz LM (2019) BRCA1 deficiency upregulates NNMT, which reprograms metabolism and sensitizes ovarian cancer cells to mitochondrial metabolic targeting agents

Because these pathways dont overlap, researchers studying one typically arent investigating the same mechanism when they study the other a distinction that matters for anyone comparing the two compounds based on keyword searches like aod vs mots c rather than on their actual mechanistic profiles

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16-week on / 4-week off: Extends into the range of the Phase IIb trial duration while building in a recovery window