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Wellness and B12 Injections Diabetes Care & Wellness Should You Take Vitamin B12 Shots? assalamuwalaikum, Metformin can reduce absorption of Vitamin B12, and this is a well established long term adverse effect. Mechanism Metformin mainly interferes with: Calcium dependent absorption of the intrinsic factorB12 complex in the terminal ileum b12 injections neuropathy The efficacy of vitamin B12 supplementation for treating vitamin B12 deficiency and peripheral
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