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Future breakthroughs should concentrate on three key areas: 1) the comprehensive integration of metabolomics, single-cell sequencing, and deep learning technologies to accurately analyze the structure-activity relationships of active molecules and their cross-organ regulatory networks

Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-Hydroxy-2-Nonenal

When the intestinal barrier function is impaired, microbial products such as LPS, bacterial DNA, and peptidoglycan can enter the bloodstream and migrate to the lungs, activating local immune responses through TLRs (152154)

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