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[DOI] [PMC free article] [PubMed] [Google Scholar] 17

It supports instructional use within research, teaching, and simulation facilities where a preserved water-based medium is required

The BBB of mice was found to be largely intact, as confirmed by various assays for leakage of components of the periphery into the CNS, including horseradish peroxidase [39, 40], immunohistochemistry [40], and radioactive tracers [41], which is why it was long believed that the cuprizone-induced demyelination occurs without peripheral involvement