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However, this method may suffer from two limitations

doi: 10.1111/j.1471-4159.2011.07189.x

Briefly, Nerve images were captured at different depths using Z-stack imaging

Additionally, during PDGF-promoted PASMC proliferation, researchers observed an increase in intracellular lactate production and accumulation, which may enhance histone lactylation at HIF-1 targets, subsequently affecting the transformation of PASMC phenotypes and ultimately leading to remodeling of the pulmonary artery [184, 192]