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Nagaraj S, et al

142.Gondhalekar C, Biela E, Rajwa B, Bae E, Patsekin V, Sturgis J, Reynolds C, Doh I-J, Diwakar P, Stanker L, Zorba V, Mao X, Russo R and Robinson JP, Anal

The stereoselective alkylation of 146 with 5-bromovaleric acid 147 in the presence of lithium diisopropylamide as a base in THF resulted in the carboxylic acid derivative 148, which was hydrolyzed in aqueous HCl to yield S -ALA