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In a nutshell, various studies confirmed implication of Glo-I and (R)AGE in inflammatory liver disease and fibrosis

de Laat V, Topal H, Spotbeen X, Talebi A, Dehairs J, Idkowiak J, et al

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In the canonical Notch signaling, the Notch ligand binding to its receptor results in the removal of the extracellular fraction, and then two protein hydrolysis by A disintegrin and metalloprotease (ADAM10/17) and subsequently by a -secretase, respectively, 233 results in the generation of the Notch active form, NICD (Notch intracellular domain)