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doi: 10.1016/S1474-4422(23)00116-3 24 JamerlanA

Nanoparticle- and liposome-carried drugs: new strategies for active targeting and drug delivery across blood-brain barrier

[43a] Taken together, the molecular consequences of MBR and WTL SOD1 mutations appear to merge into a single unifying theme underlying SOD1 protein misfolding: mutations not only disrupt SOD1 maturation to promote the accumulation of disordered immature SOD1 conformers, but may substantially accentuate structural instability within already disordered microenvironments in apoSOD1

We highlight its role in mitigating oxidative stress, regulating mitochondrial function, modulating neuroinflammatory signaling, and promoting neurogenesis and synaptic remodeling