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Two of these proteins, interleukin 12 (IL-12) and interleukin 23 (IL-23), have been implicated as important contributors to the chronic inflammation that is a main feature of ulcerative colitis

When B12 is low enough to impair those two key enzymes, mitochondrial energy production slows, red blood cell formation becomes less efficient (which means less oxygen delivery to muscles and organs), and fatigue accumulates

E11.9 (Type 2 diabetes mellitus without complications) is used when the patient has stable type 2 diabetes without documented complications

Physical therapy, desensitization, trigger-point treatment, and carefully monitored short trials of anti-inflammatory medication or muscle relaxants may help selected patients