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In conclusion, GGT and the ChaC family of GSH degrading enzymes, both intracellularly and extracellularly, are key for maintaining GSH homeostasis and serve key roles in normal cellular processes and tumor-related stress conditions

3.3 Ferroptosis and autophagy Autophagy, a process that relies on the lysosome for the degradation of cellular components, has been implicated in a spectrum of pathological conditions, including infectious diseases, immunological disorders, metabolic syndromes, and malignancies (140142)

This typically occurs in women, in the setting of malnutrition, severe sepsis, chronic alcohol use, liver or kidney failure