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Description

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide using S-adenosyl methionine (SAM)

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doi: 10.7861/clinmedicine.15-2-145

This substrate site-targeting mechanism provides selectivity over related methyltransferases and other NAD salvage pathway enzymes in laboratory assay systems