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336 Several underlying factors, such as differences in the experimental design, model systems, or patient heterogeneity, may account for the differences in the mechanisms of action of CP31398 and APR-246 and cause different therapeutic responses

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An experiment using human peripheral blood macrophages (M) showed that the intracellular GSH content was dose-dependently increased by treatment of M with cystine, and was increased further by the addition of glutamate (Rimaniol et al

This included Israel Simon Kleiner and Samuel Meltzer, two American physiologists, based at the Rockefeller University in New York who in 1915 demonstrated with animal experiments the power of intravenously administered pancreatic extracts in lowering blood sugar