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HE is primarily considered a gliopathy in which astrocyte dysfunction is the main neuropathological hallmark, while recently microglia and neuronal alterations have been reported

One of the steps of healing is to form whats called granulation tissue, and then it also forms collagen

For many opportunistic pathogens, iron starvation not only triggers activation of genes involved in its uptake, but also those involved in virulence determinants (Hassan and Troxell, 2013