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[67] Contraindications [edit] Some major contraindications for ketamine are: [28] [49] Severe cardiovascular disease such as unstable angina or poorly controlled hypertension Increased intracranial or intraocular pressure (however these remain controversial, with recent studies suggesting otherwise) [49] Poorly controlled psychosis Severe liver disease such as cirrhosis Pregnancy Active substance use disorder (for serial ketamine injections) Age less than 3 months [10] Adverse effects [edit] At anesthetic doses, 1020% of adults and 12% of children [10] experience adverse psychiatric reactions that occur during emergence from anesthesia, ranging from dreams and dysphoria to hallucinations and emergence delirium

Studies with 14C-labeled substrates in humans

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When the right peptide binds with the right receptor, it triggers a specific function, such as releasing hormones, burning fat, or increasing metabolism