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More specifically, NRF2 and KEAP1 have been analyzed in postmortem motor cortex and spinal cord specimens from ALS patients and a reduction in both NFE2L2 mRNA and NRF2 protein has been found in ALS patient tissues when compared to control ones

Eur Arch Psychiatry Clin Neurosci (2016) 266:695702

Injectable and IV routes dominate because standard oral glutathione has very low bioavailability it's largely degraded in the gut before reaching circulation

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