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[DOI] [PMC free article] [PubMed] [Google Scholar] 86.Peitl V., Sili A., Orlovi I., Vidrih B., Crnkovi D., Karlovi D

and S.B.), with additional expertise and input provided by a hepatologist (J.H.L.) who was on the Data Safety Monitoring Board of a trial investigating bardoxolone methyl, which is in the same class of semi-synthetic triterpenoid compounds as omaveloxolone

60.0%, p = 0.045) and PFS (9.2, 95% CI: 8.02 10.489 vs

Triggers of elevated ceramide levels comprise hyperosmotic shock [122], secreted sphingomyelinases (SMases) during inflammation [125], sepsis [126] or severe coronavirus disease 2019 (COVID-19) [127], Clostridium perfringens epsilon toxin [128], and platelet-activating factor [129]