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Megadoses of vitamin C strongly inhibited the Th2 responses [290], eosinophilia, and neutrophilia in OVA mice and guinea pigs, respectively [35]

This raised the question as to how cyclin D could find its substrates if its hydrophobic patch were already occupied

Previously, several CETP inhibitors, including torcetrapib, evacetrapib and anacetrapib, have been discontinued due to reasons such as side effects and poor therapeutic efficacy (130,168)