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A central role for long non-coding RNA in cancer

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Many disease-causing mutations cluster near the structural NADP binding site, destabilizing the enzyme without directly abolishing its active site

Therapeutic effects in patient-derived osteosarcoma xenograft mouse model For a better understanding of the clinical potential, its therapeutic properties were assessed in a patient-derived osteosarcoma xenograft mouse model (PDX OS ) in immunodeficient nude mice (protocol for model establishment: Fig